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Chemical remodeling of the mycomembrane with chain-truncated lipids sensitizes mycobacteria to rifampicin

https://doi.org/10.1039/D3CC02364H

Gaidhane, Ishani V; Biegas, Kyle J; Erickson, Helen E; Agarwal, Prachi; Chhonker, Yashpal S; Ronning, Donald R; Swarts, Benjamin M (November 2023, Chemical Communications)

Remodeling the notoriously impenetrable mycobacterial outer membrane with synthetic lipids enhances cellular permeability, sensitizing bacteria to the clinically used antibiotic rifampicin.
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Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift

https://doi.org/10.1021/acsinfecdis.4c00138

Kalera, Karishma; Liu, Rachel; Lim, Juhyeon; Pathirage, Rasangi; Swanson, Daniel H; Johnson, Ulysses G; Stothard, Alicyn I; Lee, Jae Jin; Poston, Anne W; Woodruff, Peter J; et al (April 2024, ACS Infectious Diseases)

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A FRET-Based Fluorogenic Trehalose Dimycolate Analogue for Probing Mycomembrane-Remodeling Enzymes of Mycobacteria

https://doi.org/10.1021/acsomega.9b00130

Holmes, Nathan J.; Kavunja, Herbert W.; Yang, Yong; Vannest, B. Dillon; Ramsey, Claudia N.; Gepford, Dana M.; Banahene, Nicholas; Poston, Anne W.; Piligian, Brent F.; Ronning, Donald R.; et al (February 2019, ACS Omega)

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